Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

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Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

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作者：Ali Salanti¹ ; ² ; ¹⁷ ; ^{salanti@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author} ; Thomas M. Clausen¹ ; ² ; ³ ; ⁴ ; ⁵ ; ¹⁷ ; Mette Ø ; . Agerbæ ; k¹ ; ² ; ³ ; ⁴ ; Nader Al Nakouzi³ ; ⁴ ; Madeleine Dahlbä ; ck¹ ; ² ; Htoo Z. Oo³ ; ⁴ ; Sherry Lee³ ; Tobias Gustavsson¹ ; ² ; Jamie R. Rich⁶ ; ⁷ ; Bradley J. Hedberg⁶ ; ⁷ ; Yang Mao⁸ ; Line Barington¹ ; ² ; Marina A. Pereira¹ ; ² ; Janine LoBello⁹ ; Makoto Endo¹⁰ ; ¹¹ ; ¹² ; ¹³ ; Ladan Fazli³ ; Jo Soden¹⁴ ; Chris K. Wang³ ; Adam F. Sander¹ ; ² ; Robert Dagil¹ ; ² ; Susan Thrane¹ ; ² ; Peter J. Holst¹ ; ² ; Le Meng⁸ ; Francesco Favero¹⁵ ; Glen J. Weiss⁹ ; ¹⁶ ; Morten A. Nielsen¹ ; ² ; Jim Freeth¹⁴ ; Torsten O. Nielsen¹⁰ ; ¹¹ ; Joseph Zaia⁸ ; Nhan L. Tran⁹ ; Jeff Trent⁹ ; John S. Babcook⁶ ; ⁷ ; Thor G. Theander¹ ; ² ; Poul H. Sorensen⁵ ; ¹⁸ ; Mads Daugaard³ ; ⁴ ; ¹⁸ ; ^{mads.daugaard@ubc.ca" class="auth_mail" title="E-mail the corresponding author}
刊名：Cancer Cell
出版年：2015
出版时间：12 October 2015
年：2015
卷：28
期：4
页码：500-514
全文大小：6739 K

文摘

•: The placenta and cancer express a similar type of oncofetal chondroitin sulfate
•: Oncofetal chondroitin sulfate is displayed on proteoglycans in cancer
•: Recombinant VAR2CSA proteins detect oncofetal chondroitin modifications
•: Human cancer can be broadly targeted by malarial VAR2CSA drug conjugates in vivo

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