The paper describes the information system and interoperability related challenges, trends and issues that must be addressed to support a new generation of scientific-based and technological solutions for facilitating the collaboration of existing enterprise systems.

This paper presents general research priorities and directions of related to context-aware systems, semantic interoperability, cyber-physical systems, cloud-based systems and interoperability assessment.

The listed properties are used to propose the generic abstract architecture of the Next Generation Enterprise Information Systems.