Sticking Around: Short-Range Activity of Wnt Ligands

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• 作者：Michael Boutros¹ ; ^{m.boutros@dkfz.de" class="auth_mail" title="E-mail the corresponding author} ; Christof Niehrs² ; ³
• 刊名：Developmental Cell
• 出版年：2016
• 出版时间：7 March 2016
• 年：2016
• 卷：36
• 期：5
• 页码：485-486
• 全文大小：171 K

文摘

Wnt ligands are secreted lipid-modified proteins that are essential for development and homeostasis. Published recently in Nature, Farin et al. (2016) report that Wnt3 acts at a short distance during growth of mouse intestinal organoids, suggesting that Wnt proteins remain membrane-bound to activate signaling at a short range from their source.