Stereoselectivity in the formation and radical reduction of cyclic bromoacetals, key intermediates for the synthesis of δ-hydroxy- and ?-hydroxy-α-methylcarboxylic acid esters

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• 作者：Nagano ; Hajime ; Mikami ; Ayako ; Yajima ; Tomoko
• 关键词：radical reaction ; cyclic bromoacetal ; remote asymmetric induction ; δ ; -hydroxy-α ; -methylcarboxylic acid ester ; ?-hydroxy-α ; -methylcarboxylic acid ester
• 刊名：Tetrahedron Letters
• 出版年：2003
• 出版时间：September 1, 2003
• 年：2003
• 卷：44
• 期：36
• 页码：6867-6870
• 全文大小：144 K

文摘

We report the stereoselectivity in the formation and radical reduction of six- and seven-membered cyclic bromoacetals. The oxidative ring cleavage of the resulting acetals gave the corresponding acyclic δ-hydroxy- and ?-hydroxy-α-methylcarboxylic acid esters.