PM_2.5 exposure-induced autophagy is mediated by lncRNA loc146880 which also promotes the migration and invasion of lung cancer cells

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• 作者：Xiaobei Deng^a ; ^{dengxiaobei@126.com} ; Nannan Feng^a ; ^{fengnan214@163.com} ; Min Zheng^a ; ^{zhengmin8010@126.com} ; Xiaofei Ye^a ; ^{fly0770@163.com} ; Hongyan Lin^a ; ^{cara-chris@sjtu.edu.cn} ; Xiao Yu^a ; ^{yuxiao19910101@163.com} ; Zhihua Gan^b ; ^{zhgan@mail.buct.edu.cn} ; Zheng Fang^c ; ^{shiningbluedan@hotmail.com} ; Huan Zhang^d ; ^{brenda1919@163.com} ; Ming Gao^d ; ^{gaoming68@aliyun.com} ; Zhi-jie Zheng^a ; ^{zheng22762@icloud.com} ; Herbert Yu^e ; ^{hyu@cc.hawaii.edu} ; Wenjun Ding^f ; ^{dingwj@ucas.ac.cn} ; Biyun Qian^a ; ¹ ; ^{qianbiyun@shsmu.edu.cn}
• 关键词：DAPI ; 4 ; 6-diamido-2-phenylindole hydrochloride ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorofluorescein diacetate ; EMT ; epithelial-mesenchymal transition ; ESR ; electron spin resonance spectroscopy ; ICP-MS ; inductively coupled plasma-mass spectrometry ; LC3 ; microtubule-associated proteins light chain 3 ; LncRNAs ; long non-coding RNAs ; NAC ; N-acetylcysteine ; O2&bull ; - ; superoxide anion ; OH ; hydroxyl radical ; PM ; ambient airborne particulate matter ; ROS ; reactive oxygen species ; SEM ; scanning electron micr
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1861
• 期：2
• 页码：112-125
• 全文大小：2178 K
• 卷排序：1861

文摘

PM2.5 exposure increases ROS production, which up-regulates a lncRNA named loc146880. Loc146880 increases the autophagy of A549 cells. PM2.5-induced ROS and loc146880 promote cell migration, invasion and EMT.