FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N⁶-Methyladenosine RNA Demethylase

详细信息    查看全文

• 作者：Zejuan Li¹ ; ⁷ ; ¹⁰ ; Hengyou Weng¹ ; ² ; ¹⁰ ; Rui Su² ; ¹⁰ ; Xiaocheng Weng³ ; ⁸ ; ¹⁰ ; Zhixiang Zuo¹ ; ² ; ⁹ ; ¹⁰ ; Chenying Li² ; ⁴ ; Huilin Huang² ; Sigrid Nachtergaele³ ; Lei Dong² ; Chao Hu¹ ; ² ; ⁴ ; Xi Qin² ; Lichun Tang⁵ ; Yungui Wang¹ ; ² ; ⁴ ; Gia-Ming Hong¹ ; Hao Huang¹ ; Xiao Wang³ ; Ping Chen¹ ; Sandeep Gurbuxani⁶ ; Stephen Arnovitz¹ ; Yuanyuan Li¹ ; Shenglai Li¹ ; Jennifer Strong² ; Mary Beth Neilly¹ ; Richard A. Larson¹ ; Xi Jiang¹ ; ² ; Pumin Zhang⁵ ; Jie Jin⁴ ; Chuan He³ ; ^{chuanhe@uchicago.edu} ; Jianjun Chen¹ ; ² ; ¹¹ ; ^{chen3jj@ucmail.uc.edu}
• 关键词：FTO ; AML ; m6A ; RNA modification ; ASB2 ; RARA ; leukemogenesis ; ATRA ; cell differentiation ; RNA stability
• 刊名：Cancer Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：127-141
• 全文大小：6294 K
• 卷排序：31

文摘

FTO is highly expressed in certain subtypes of AMLs such as MLL-rearranged AML FTO promotes leukemic oncogene-mediated cell transformation and leukemogenesis FTO targets a set of genes (e.g., ASB2 and RARA) in AML as an m6A RNA demethylase The FTO⊣ASB2/RARA axis mediates AML cell growth and (ATRA-induced) differentiation