MicroRNA-24 inhibits serotonin reuptake transporter expression and aggravates irritable bowel syndrome

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MicroRNA-24 inhibits serotonin reuptake transporter expression and aggravates irritable bowel syndrome

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作者：Xiu-Jun Liao ; ^{xiujunliao@163.com" class="auth_mail" title="E-mail the corresponding author} ; Wei-Ming Mao ; Qin Wang ; Guan-Gen Yang ; Wen-Jing Wu ; Shu-Xian Shao
关键词：Irritable bowel syndrome ; miR-24 ; Mouse model ; SERT
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：8 January 2016
年：2016
卷：469
期：2
页码：288-293
全文大小：865 K

文摘

•: MiR-24 is upregulated in intestinal mucosa epithelial cells of IBS patients and mice.
•: MiR-24 targets SERT mRNA and regulates its expression.
•: MiR-24 inhibitor alleviates intestinal pain and inflammation in IBS mice.

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