Synchronous helicity control in zinc bilinone trimer

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• 作者：Katsushi Hamakubo ; Shigeyuki Yagi ; Hiroyuki Nakazumi ; Tadashi Mizutani and Susumu Kitagawa
• 关键词：Zinc bilinone ; Tripodal spacer ; Homohelicity induction ; Preorganization
• 刊名：Tetrahedron Letters
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：46
• 期：42
• 页码：7151-7154
• 全文大小：197 K

文摘

In order to develop an artificial signal transmission/amplification system triggered by chiral recognition, we synthesized a series of zinc bilinone (ZnBL) trimers bearing a tripodal spacer and investigated homohelicity induction by complexation with chiral α-amino esters. Controlling the length of the peripheral alkyl groups in ZnBL moieties led to preorganization of the trimer to homohelical conformers. In addition, complexation with chiral α-amino esters induced the formation of the chiral homohelical conformer in which three ZnBL moieties adopted the same helicity.