Repair genes expression profile of MLH1, MSH2 and ATM in the normal oral mucosa of chronic smokers

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• 作者：Mô ; nica Ghislaine Oliveira Alves^a ; ^b ; ^{mgoliveiraalves@gmail.com} ; Celina Faig Lima Carta^a ; Patrí ; cia Pimentel de Barros^a ; Jaqueline Scholz Issa^c ; Fá ; bio Daumas Nunes^d ; Janete Dias Almeida^a
• 关键词：Carcinoma ; Squamous cell ; Smoking ; Gene expression immunocytochemistry
• 刊名：Archives of Oral Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：60-65
• 全文大小：1225 K
• 卷排序：73

文摘

Exfoliative cytology may be useful for the detection and monitoring of early changes in smokers. Exfoliative cytology may be useful for the detection and monitoring of early changes in smokers. Chronic smoking decreases the expression of the DNA repair genes MLH1, MSH2 and ATM. This decreased expression may influence DNA repair capacity with consequent carcinogenesis development.