HIV aspartic peptidase inhibitors are effective drugs against the trypomastigote form of the human pathogen Trypanosoma cruzi

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HIV aspartic peptidase inhibitors are effective drugs against the trypomastigote form of the human pathogen Trypanosoma cruzi

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作者：Leandro S. Sangenito^a ; Diego S. Gonç ; alves^a ; ^b ; Sergio H. Seabra^c ; Claudia M. d'Avila-Levy^d ; André ; L.S. Santos^a ; ^b ; ¹ ; ^{andre@micro.ufrj.br" class="auth_mail" title="E-mail the corresponding author} ; Marta H. Branquinha^a ; ¹ ; ^{mbranquinha@micro.ufrj.br" class="auth_mail" title="E-mail the corresponding author}
关键词：Trypanosoma cruzi ; HIV peptidase inhibitor ; Aspartic peptidase ; Proteasome ; Morphological alterations
刊名：International Journal of Antimicrobial Agents
出版年：2016
出版时间：October 2016
年：2016
卷：48
期：4
页码：440-444
全文大小：1027 K

文摘

•: An alternative chemotherapy to treat Chagas' disease is proposed.
•: HIV aspartic peptidase inhibitors (PIs) reduce the viability of Trypanosoma cruzi trypomastigotes.
•: HIV-PIs caused many morphological/ultrastructural alterations in trypomastigotes.
•: Nelfinavir and lopinavir target aspartic peptidases and proteasomes of T. cruzi.

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