Diabetes-induced hepatic oxidative stress: a new pathogenic role for glycated albumin

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• 作者：Jessica Patche^a ; Dorothé ; e Girard^a ; Auré ; lie Catan^a ; Florence Boyer^a ; Anthony Dobi^a ; Cynthia Planesse^a ; Nicolas Diotel^a ; Alexis Guerin-Dubourg^a ; ^b ; Pascal Baret^a ; Susana B. Bravo^c ; Beatriz Paradela-Dobarro^c ; Ezequiel Á ; lvarez^c ; M. Faadiel Essop^d ; Olivier Meilhac^a ; ^e ; Emmanuel Bourdon^a ; ¹ ; ^{emmanuel.bourdon@univ-reunion.fr} ; Philippe Rondeau^a ; ¹ ; ^{rophil@univ-reunion.fr}
• 关键词：4-HNE ; 4-hydroxynonenal ; ACB ; albumin cobalt binding ; AGE ; advanced glycation end-product ; AOPP ; advanced oxidation end-products ; DCF ; dichlorofluorescein ; DHE ; dihydroethidium ; GSH ; reduced glutathione ; GSSG ; oxidized glutathione ; HSA ; human serum albumin ; HT ; hemolysis time ; IL-6 ; interleukin-6 ; iNOS ; inducible nitric oxyde synthase ; MSA ; mouse albumin ; NAFLD ; non-alcoholic fatty liver disease ; O2° ; - ; superoxide anion ; PGC1α ; peroxisome proliferator-activated receptor-gamma coactivator 1-al
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：133-148
• 全文大小：2090 K
• 卷排序：102

文摘

High oxidative stress and lipid accumulation in plasma and livers of diabetic mice. Albumin modifications in diabetic mice resembled those found in diabetic patients. Exposure of human hepatoma cells to glycated albumin elicited oxidative damages.