Relationship between imatinib trough concentration and outcomes in the treatment of advanced gastrointestinal stromal tumours in a real-life setting

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Relationship between imatinib trough concentration and outcomes in the treatment of advanced gastrointestinal stromal tumours in a real-life setting

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作者：Sté ; phane Bouchet^a ; ^b ; ^c ; ¹ ; Sylvie Poulette^a ; ¹ ; Karine Titier^a ; ^b ; ^c ; Nicholas Moore^a ; ^b ; ^c ; Ré ; gis Lassalle^a ; ^d ; Abdelilah Abouelfath^a ; ^d ; Antoine Italiano^e ; Christine Chevreau^f ; Emmanuelle Bompas^g ; Olivier Collard^h ; Florence Duffaudⁱ ; ^j ; Maria Rios^k ; Didier Cupissol^l ; Antoine Adenis^m ; Isabelle Ray-Coquardⁿ ; ^o ; Olivier Bouché ; ^p ; Axel Le Cesne^q ; Binh Bui^e ; Jean-Yves Blayⁿ ; ^o ; Mathieu Molimard^a ; ^b ; ^c ; ^{mathieu.molimard@u-bordeaux.fr" class="auth_mail" title="E-mail the corresponding author}
关键词：Imatinib ; Gastrointestinal stromal tumour ; Therapeutic drug monitoring
刊名：European Journal of Cancer
出版年：2016
出版时间：April 2016
年：2016
卷：57
期：Complete
页码：31-38
全文大小：593 K

文摘

•: Definition of an imatinib threshold is proposed in a real-life setting.
•: An imatinib Cmin threshold of 760 ng/ml was associated with longer progression-free survival (PFS) in gastrointestinal stromal tumours (GISTs).
•: Same threshold associated with longer PFS for both stomach and small bowel localisations.
•: Imatinib therapeutic drug monitoring may be useful in real-life settings for GISTs treatment management.

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