Generation and characterization of a human-mouse chimeric antibody against the extracellular domain of claudin-1 for cancer therapy using a mouse model

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Generation and characterization of a human-mouse chimeric antibody against the extracellular domain of claudin-1 for cancer therapy using a mouse model

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作者：Yosuke Hashimoto^a ; ¹ ; Minoru Tada^b ; ¹ ; Manami Iida^a ; ¹ ; Shotaro Nagase^a ; Tomoyuki Hata^a ; Akihiro Watari^a ; Yoshiaki Okada^a ; Takefumi Doi^a ; Masayoshi Fukasawa^c ; Kiyohito Yagi^a ; Masuo Kondoh^a ; ^{masuo@phs.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
关键词：Claudin-1 ; Chimeric antibody ; Anti-cancer agent ; Fcγ receptor IIIa
刊名：Biochemical and Biophysical Research Communications
出版年：2016
出版时间：12 August 2016
年：2016
卷：477
期：1
页码：91-95
全文大小：894 K

文摘

•: Claudin-1 is a useful target for treating tumors.
•: Human–mouse chimeric anti-claudin-1 monoclonal antibody that induced antibody-dependent cellular cytotoxicity was generated.
•: The chimeric anti-claudin-1 monoclonal antibody showed anti-tumor effect in tumor xenograft model mice.