Short-term enriched environment exposure facilitates fear extinction in adult rats: The NPY-Y1 receptor modulation

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Short-term enriched environment exposure facilitates fear extinction in adult rats: The NPY-Y1 receptor modulation

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作者：Gilliard Lach^a ; ^{Gilliard.Lach@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author} ; Maira Assunç ; ã ; o Bicca^a ; Alexandre Ademar Hoeller^a ; ^b ; Evelyn Cristina da Silva Santos^a ; Ana Paula Ramos Costa^a ; Thereza Christina Monteiro de Lima^a
关键词：CFC ; contextual fear conditioning ; CS ; conditioned stimulus ; EE ; enriched environment ; NPY ; neuropeptide Y ; PTSD ; post-traumatic stress disorder ; RIPA ; radio immunoprecipitation lysis buffer ; SE ; standard environment ; US ; unconditioned stimulus ; Y1r ; NPY-Y1 receptor ; BIBO ; BIBO3304 ; US ; unconditioned stimulus ; CS ; conditioned stimulus ; CRH ; corticotrophin-releasing hormone
刊名：Neuropeptides
出版年：2016
出版时间：February 2016
年：2016
卷：55
期：Complete
页码：73-78
全文大小：515 K

文摘

•: Short-term enriched environment exposure facilitates contextual fear extinction.
•: Enriched environment-induced facilitation of fear extinction is reverted by central blockade of NPY-Y1 receptors.
•: Enriched environment induces upregulation of hippocampal NPY-Y1 receptors after fear conditioning.

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