Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10

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• 作者：Xiao-liang Wang^a ; Qing Liu^a ; ^{qingliu5566@aliyun.com} ; Guo-Jun Chen^b ; Mei-ling Li^a ; Yan-hui Ding^a
• 关键词：Alzheimer's disease ; Amyloid precursor protein ; MTERF4 ; ADAM10 ; BACE1
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：928-934
• 全文大小：968 K
• 卷排序：482

文摘

MTERF4 expression is upregulated in an animal model of Alzheimer's disease. MTERF4 overexpression suppresses the α-site cleavage of APP. MTERF4 overexpression reduces ADAM10 transcription. Dysfunction of MTERF4 may contribute to the pathophysiology of Alzheimer's disease.