Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals

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Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals

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作者：Zhiyong Zheng^a ; Liang Shi^a ; Yuchen Sheng^b ; Jiaqi Zhang^a ; Bin Lu^a ; Lili Ji^a ; ^{lichenyue1307@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：ALT/AST ; alanine/aspartate aminotransferase ; CGA ; chlorogenic acid ; Egr1 ; early growth response1 ; GCL ; glutamate cysteine ligase ; H&E ; hematoxylin-eosin ; HSCT ; hematopoietic stem cell transplantation ; HVOD ; hepatic veno-occlusive obstruction ; IκB ; inhibitor of kappa B ; IL-1β ; interleukin-1β ; LPO ; lipid peroxidation ; MAPKs ; mitogen-activated protein kinases ; MCT ; monocrotaline ; MDA ; malondialdehyde ; MMP-9 ; metalloproteinase-9 ; MOF ; multiorgan failure ; MPO ; myeloperoxidase ; MyD88 ; myeloid differen
刊名：Environmental Toxicology and Pharmacology
出版年：2016
出版时间：September 2016
年：2016
卷：46
期：Complete
页码：80-89
全文大小：3728 K

文摘

•: CGA attenuated MCT-induced SOS in rats.
•: CGA attenuated MCT-induced hepatic inflammation and oxidative injury.
•: CGA inhibited MCT-induced transcriptional activation of NFκB and Egr1.
•: CGA enhanced Nrf2 transcriptional activation.
•: CGA abrogated MCT-induced activation of MAPKs and PI3K signaling pathways.