Nitration of MOG diminishes its encephalitogenicity depending on MHC haplotype

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• 作者：Andreas Warnecke^a ; Sravani Musunuri^b ; Marie N'diaye^a ; Tatyana Sandalova^c ; Adnane Achour^c ; Jonas Bergquist^b ; Robert A Harris^a ; ^{Robert.Harris@ki.se}
• 关键词：EAE ; experimental autoimmune encephalomyelitis ; ESI-MS/MS ; ElectroSpray Ionization tandem Mass Spectrometry ; iNOS ; inducible nitric oxide synthase ; MBP ; Myelin basic protein ; MHC ; Major histocompatibility complex ; MS ; Multiple Sclerosis ; NIY ; nitrotyrosine ; pI ; isoelectric point ; PLP ; Myelin Proteolipid protein ; rmMOG ; recombinant mouse Myelin Oligodendrocyte Glycoprotein ; RNS ; reactive nitrogen species ; ROS ; Reactive oxygen species ; SDS-PAGE ; Sodium dodecyl sulfate (denaturing) Poly Acrylamide
• 刊名：Journal of Neuroimmunology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：303
• 期：Complete
• 页码：1-12
• 全文大小：1736 K
• 卷排序：303

文摘

Unique study addressing the impact of antigen nitration in EAE/MS Nitrated MOG is poorly encephalitogenic in H2b C57BL/6 mice. The nitrated MOG35–55p40NIY altered peptide ligand does not induce EAE. H2q mice remain fully susceptible to EAE with nitrated MOG (MHC-dependent effect!). Mechanism explained using molecular MHC modeling.