Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2

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Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2

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作者：Steven A. Connor¹ ; ² ; ⁹ ; Ina Ammendrup-Johnsen¹ ; ⁹ ; Allen W. Chan¹ ; ² ; ⁹ ; Yasushi Kishimoto³ ; ⁹ ; Chiaki Murayama⁴ ; ⁵ ; Naokazu Kurihara³ ; Atsushi Tada³ ; Yuan Ge¹ ; Hong Lu¹ ; Ryan Yan¹ ; Jeffrey M. LeDue¹ ; Hirotaka Matsumoto⁵ ; Hiroshi Kiyonari⁶ ; ⁷ ; Yutaka Kirino³ ; Fumio Matsuzaki⁸ ; Toshiharu Suzuki⁵ ; Timothy H. Murphy¹ ; Yu Tian Wang² ; ^{ytwang@brain.ubc.ca" class="auth_mail" title="E-mail the corresponding author} ; Tohru Yamamoto⁴ ; ^{tohru@med.kagawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Ann Marie Craig¹ ; ^{acraig@mail.ubc.ca" class="auth_mail" title="E-mail the corresponding author}
刊名：Neuron
出版年：2016
出版时间：7 September 2016
年：2016
卷：91
期：5
页码：1052-1068
全文大小：6450 K

文摘

•: Autism-linked MDGA2 negatively regulates the NLGN-NRXN synaptic pathway
•: Mdga2^+/− mice show increased excitatory synapse number and function and altered LTP
•: Mdga2^+/− mice represent a heterozygous model with an autism-like behavior phenotype
•: In vivo imaging reveals enhanced activity and hyperconnectivity in Mdga2^+/− cortex

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