Porphyromonas gingivalis Promotes Unrestrained Type I Interferon Production by Dysregulating TAM Signaling via MYD88 Degradation

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• 作者：Gabriel Mizraji¹ ; ² ; Maria Nassar¹ ; Hadas Segev¹ ; Hafiz Sharawi² ; Luba Eli-Berchoer¹ ; Tal Capucha¹ ; Tsipora Nir¹ ; Yaara Tabib¹ ; Avraham Maimon¹ ; Shira Dishon¹ ; Lior Shapira² ; Gabriel Nussbaum¹ ; Asaf Wilensky² ; ^{asafw@ekmd.huji.ac.il} ; Avi-Hai Hovav¹ ; ³ ; ^{avihaih@ekmd.huji.ac.il}
• 关键词：oral mucosa ; mucosal immunity ; periodontitis ; Porphyromonas gingivalis ; MYD88 ; interferon ; GAS6
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：419-431
• 全文大小：3872 K
• 卷排序：18

文摘

Type I interferons are upregulated in P. gingivalis-induced periodontitis in mice P. gingivalis causes degradation of MYD88 in the gingival epithelium MYD88 is required for AXL and GAS6 expression, regulators of type I interferons Blocking type I interferon signaling prevents experimental periodontitis