Expression of long-term potentiation of the striatum in methamphetamine-sensitized rats

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• 作者：Nishioku ; Tsuyoshi ; Shimazoe ; Takao ; Yamamoto ; Yasuharu ; Nakanishi ; Hiroshi ; Watanabe ; Shigenori
• 关键词：Long-term potentiation ; Striatum ; Methamphetamine ; Sensitization ; N-Methyl-d-aspartate ; Long-term depression
• 刊名：Neuroscience Letters
• 出版年：1999
• 出版时间：June 18, 1999
• 年：1999
• 卷：268
• 期：2
• 页码：81-84
• 全文大小：127 K

文摘

We examined the change of corticostriatal glutamatergic neuronal transmission in striatal slices of methamphetamine (MAP)-sensitized rats in vitro. Tetanic stimulation induced long-term depression (LTD) of the field potential in the striatum of saline-treated rats. However, it induced long-term potentiation (LTP) in the striatum of MAP-sensitized rats. This LTP was significantly suppressed by a N-methyl-d-aspartate (NMDA) receptor antagonist, aminophosphonovaleric acid (APV). These results suggest that LTP is expressed in the striatum of MAP-sensitized rats, and that NMDA receptors are indispensable for the LTP formation.