Vascular endothelial cells constitutively express the NALP3 inflammasome.

The NALP3 inflammasome in vascular endothelial cells can respond to specific danger signals including monosodium urate crystals.

The NALP3 inflammasome is not responsible for the activation of vascular endothelial cells in response to necrotic trophoblastic debris.

IL-1β derived from necrotic trophoblastic debris contributes to endothelial cell activation in response to the debris.

The IL-1β derived from necrotic trophoblastic debris may contribute to maternal endothelial cell dysfunction in preeclampsia.