Thyroid hormone disruption and cognitive impairment in rats exposed to PBDE during postnatal development

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Thyroid hormone disruption and cognitive impairment in rats exposed to PBDE during postnatal development

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作者：Andressa S. de-Miranda ; Sergio N. Kuriyama ; Camille S. da-Silva ; Monicke S.C. do-Nascimento ; Thiago E.M. Parente ; Francisco J.R. Paumgartten ; ^{paum@ensp.fiocruz.br" class="auth_mail" title="E-mail the corresponding author} ; ^{francpaum@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：bw ; body weight ; CNS ; central nervous system ; DIO ; iodo-thyronine deiodinase ; EROD ; ethoxyresorufin-O-dealkylase ; GD ; gestation day ; OF ; open field test ; PBDE ; polybrominated diphenyl ether ; PCBs ; polychlorinated biphenyls ; PCDD/Fs ; polychlorinated dibenzo-p-dioxins/furans ; POPs ; persistent organic pollutants ; PROD ; pentoxy-resorufin-O-dealkylase ; PND ; postnatal day ; PTU ; n-propylthiouracil ; RAM ; eight-arm radial maze ; T4 ; thyroxine ; T3 ; triiodothyronine ; TSH ; thyroid stimulating hormone ; UGT ; u
刊名：Reproductive Toxicology
出版年：2016
出版时间：August 2016
年：2016
卷：63
期：Complete
页码：114-124
全文大小：1150 K

文摘

•: Hypothyroxinemia during post-natal development leads to hyperactivity and cognitive deficits.
•: Pre-weaning exposure to PBDEs results in persistent cognitive deficits in female rats.
•: Thyroxine (T4) replacement prevents neurodevelopmental toxic effects of PBDEs.
•: T4 prevents long-lasting cognitive impairment due to hypothyroidism after birth.

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