Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease

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Knock-down of pantothenate kinase 2 severely affects the development of the nervous and vascular system in zebrafish, providing new insights into PKAN disease

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作者：Daniela Zizioli^a ; ^{daniela.zizioli@unibs.it" class="auth_mail" title="E-mail the corresponding author} ; Natascia Tiso^b ; Adele Guglielmi^a ; Claudia Saraceno^a ; Giorgia Busolin^b ; Roberta Giuliani^a ; Deepak Khatri^a ; Eugenio Monti^a ; Giuseppe Borsani^a ; Francesco Argenton^b ; Dario Finazzi^a ; ^c ; ^{dario.finazzi@unibs.it" class="auth_mail" title="E-mail the corresponding author}
关键词：Pank2 ; NBIA ; Neurodegeneration ; Coenzyme A ; Pantethine ; Morpholino ; Zebrafish
刊名：Neurobiology of Disease
出版年：2016
出版时间：January 2016
年：2016
卷：85
期：Complete
页码：35-48
全文大小：2214 K

文摘

•: Zebrafish pank2 gene is highly expressed in the CNS and the main vascular structures.
•: Pank2 down-regulation severely affects the development of the forebrain.
•: Pank2 down-regulation affects the dorsal aorta, caudal vein and inter-somitic vessels.
•: Pantethine and Coenzyme A restore the normal development in the absence of pank2 expression.