Su.72. CEACAM-1 Expression in NK Cells and CD3+ Cells from Patients with Recurrence of Cervical Intraepithelial Neoplasia II-III (CIN II-III) after Treatment

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• 作者：Alicia del Toro-Arreola ; Angel Suarez-Rincon ; Margarita Jimenez-Perez ; Susana Del Toro Arreola ; Hector Vazquez-Martinez ; Rebeca Robles-Garcia ; Adrian Daneri Navarro
• 关键词：Aluminum toxicity ; Phospholipase D ; Microtubules
• 刊名：Clinical Immunology
• 出版年：2008
• 出版时间：2008
• 年：2008
• 卷：127
• 期：Supplement 1
• 页码：S147-S148
• 全文大小：45 K

文摘

Aluminum is a highly cytotoxic metal to plants, but the molecular base and the primary target of Al toxicity are still unknown. The most important physiological consequence of Al toxicity is a cessation of root growth and changes in root morphology suggesting a role of the root cytoskeleton as a target structure. The important role of phospholipid degrading enzyme phospholipase D in regulation of cytoskeleton remodelling in both animal and plant organisms is now evident. Both the phospholipid pathway and the cytoskeleton are influenced by Al³⁺, but their relationship with Al stress remains to be explored. Therefore, we tested the possibility that Al stress could be sensed by plants through microtubules in close interaction with phospholipases. We have shown that Al³⁺ reduced the formation of phosphatidic acid in vivo, inhibited activity of phosphatidylinositol-4,5-bisphosphate-dependent phospholipase D in vitro and that the phosphatidic acid production is modified by microtubule dynamics.