Synthesis of pyrimidine-2,4,6-trione derivatives: Anti-oxidant, anti-cancer, α-glucosidase, β-glucuronidase inhibition and their molecular docking studies

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Synthesis of pyrimidine-2,4,6-trione derivatives: Anti-oxidant, anti-cancer, α-glucosidase, β-glucuronidase inhibition and their molecular docking studies

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作者：Assem Barakat^a ; ^b ; ^{ambarakat@ksu.edu.sa" class="auth_mail" title="E-mail the corresponding author} ; Mohammad Shahidul Islam^a ; Abdullah Mohammed Al-Majid^a ; Hazem A. Ghabbour^c ; Sammer Yousuf^d ; Mahwish Ashraf^d ; Nimra Naveed Shaikh^d ; M. Iqbal Choudhary^a ; ^d ; Ruqaiya Khalil^e ; Zaheer Ul-Haq^e
关键词：Pyrimidine-2 ; 4 ; 6-trione ; Anti-oxidant ; Anti-cancer ; α-Glucosidase inhibitor ; β-Glucuronidase inhibitor
刊名：Bioorganic Chemistry
出版年：2016
出版时间：October 2016
年：2016
卷：68
期：Complete
页码：72-79
全文大小：1450 K

文摘

•: A series of pyrimidine-2,4,6-trione scaffold were synthesized.
•: X-ray crystal structure of 3j, 3n and 3o were reported.
•: Compound 3m (IC₅₀ = 22.9 ± 0.5 μM) was identified as α-glucusidase inhibitor.
•: Compound 3f (IC₅₀ = 86.9 ± 4.33 μM) was identified as β-glucuronidase inhibitor.
•: Molecular docking was carried out to investigate bonding mode of barbiturate acid.