Synthesis and spectroscopic DNA binding investigations of dibutyltin N-(5-chlorosalicylidene)-leucinate

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• 作者：Shufang Zhang^a ; ^{zhshf999@sina.com} ; Hongyu Yuan^b ; Laijin Tian^a
• 关键词：Dibutyltin N-(5-chlorosalicylidene)-leucinate ; Calf thymus DNA ; Binding mode ; UV&ndash ; spectroscopy ; Fluorescence spectroscopy
• 刊名：Journal of Molecular Structure
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：1130
• 期：Complete
• 页码：760-764
• 全文大小：750 K
• 卷排序：1130

文摘

Dibutyltin N-(5-chlorosalicylidene)-leucinate was synthesized and characterized by elemental analysis, IR, 1H NMR (1H, 13C and 119Sn) spectra. Dibutyltin N-(5-chlorosalicylidene)-leucinate could insert into DNA base pairs to form a binary complex at physiological pH. The acting force between dibutyltin N-(5-chlorosalicylidene)-leucinate and DNA mainly included hydrophobic interactions. The viscosity of DNA was enhanced with increasing the concentrations of the dibutyltin N-(5-chlorosalicylidene)-leucinate. The interaction between dibutyltin N-(5-chlorosalicylidene)-leucinate and ctDNA might occur via intercalative mode.