Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration

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• 作者：Nilkantha Sen ^{nsen@augusta.edu}
• 关键词：H2S ; hydrogen sulfide ; CSE ; cystathionine gamma-lyase ; CBS ; cystathionine beta-synthase ; 3-MST ; 3-mercaptopyruvate sulfurtransferase ; KO ; knockout ; IR ; ischemia&ndash ; reperfusion ; PC ; post-conditioning ; EC ; endothelial cell ; NRF2 ; nuclear factor erythroid 2-related factor 2 ; HG ; hyperglycemia ; TG ; triglyceride ; Con A ; concanavalin A ; TNFα ; tumor necrosis factor-α ; LSD ; lysosomal storage disorder ; TBI ; traumatic brain injury ; TFAM ; mitochondrial transcription factor A ; BBB ; blood&ndash ; brain barr
• 刊名：Journal of Molecular Biology
• 出版年：2017
• 出版时间：17 February 2017
• 年：2017
• 卷：429
• 期：4
• 页码：543-561
• 全文大小：890 K
• 卷排序：429

文摘

H2S, a newly discovered gaso-neurotransmitter, signals inside the cells mostly via sulfhydration of proteins. Modulation of autophagy by H2S signaling pathway is implicated in ischemia, myocardial fibrosis, metabolic disorders, and traumatic brain injury. H2S affects cellular metabolism, which affects tumor growth and angiogenesis. The maintenance, proliferation, and differentiation of stem cells are regulated by H2S. The influence of H2S signaling in cell cycle and cell death pathways is associated with cancer and neurodegenerative diseases.