Deubiquitinase USP12 promotes LPS induced macrophage responses through inhibition of IκBα
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文摘
USP12 levels are significantly altered in LPS stimulated macrophages. USP12 is required for LPS induced iNOS and IL6 expression. USP12 is crucial for LPS induced phosphorylation of IκBα, ERK1/2, p38.
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