A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

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A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

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作者：Chenhui Ji^a ; Guo-Fang Xue^a ; Cao Lijun^a ; Peng Feng^a ; Dongfang Li^a ; Lin Li^c ; Guanglai Li^a ; ^{smuneu@163.com" class="auth_mail" title="E-mail the corresponding author} ; Christian Hö ; lscher^a ; ^b
关键词：Insulin ; Apoptosis ; Incretin ; Growth factor ; AKT ; Neuron
刊名：Brain Research
出版年：2016
出版时间：1 March 2016
年：2016
卷：1634
期：Complete
页码：1-11
全文大小：1971 K

文摘

•: GLP-1 incretin analogues are on the market as treatments for diabetes.
•: First clinical trials show good effects in patients with Parkinson′s.
•: Novel dual-agonists have been developed that are superior.
•: We show that a novel GLP-1/GIP analogue shows good effects in a mouse model of PD.
•: Motor activity is protected, BDNF levels and Akt activity is increased by the drug.

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