Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers

详细信息    查看全文

• 作者：Jessica Dennis ; Parviz Ghadirian ; Julian Little ; Jan Lubinski ; Jacek Gronwald ; Charmaine Kim-Sing ; William Foulkes ; Pal Moller ; Henry T. Lynch ; Susan L. Neuhausen ; Susan Domchek ; Susan Armel ; Claudine
• 关键词：BRCA1 ; BRCA2 ; Alcohol ; Breast cancer ; Case-control ; Wine
• 刊名：The Breast
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：19
• 期：6
• 页码：479-483
• 全文大小：182 K

文摘

Alcohol consumption increases the risk of breast cancer among women in the general population, but its effect on women who carry a BRCA gene mutation is unclear. We conducted a case-control study of 1925 matched pairs of predominantly premenopausal women who carry a BRCA1 or a BRCA2 mutation. Information on current alcohol consumption was obtained from a questionnaire administered during the course of genetic counselling or at the time of enrolment. A modest inverse association between breast cancer and reported current alcohol consumption was observed among women with a BRCA1 mutation (OR = 0.82, 95 % CI 0.70–0.96), but not among women with a BRCA2 mutation (OR = 1.00; 95 % CI 0.71–1.41). Compared to non-drinkers, exclusive consumption of wine was associated with a significant reduction in the risk of breast cancer among BRCA1 carriers (p-trend = 0.01). Alcohol consumption does not appear to increase breast cancer risk in women carrying a BRCA gene mutation.