Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT<sub>2C</sub> receptor (5-HT<sub>2C</sub>R) system

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Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT_2C receptor (5-HT_2CR) system

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作者：S.E. Swinford-Jackson^a ; N.C. Anastasio^a ; ^b ; R.G. Fox^a ; S.J. Stutz^a ; K.A. Cunningham^a ; ^b ; ^{kcunning@utmb.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：5-HT ; serotonin ; 5-HT2CR ; 5-HT2C receptor ; ANOVA ; analysis of variance ; FA ; forced abstinence ; FR ; fixed ratio ; GABA ; γ-aminobutyric acid ; i.p. ; intraperitoneal ; mPFC ; medial prefrontal cortex ; NAc ; nucleus accumbens ; TBS ; Tris-Buffered Saline
刊名：Neuroscience
出版年：2016
出版时间：2 June 2016
年：2016
卷：324
期：Complete
页码：50-61
全文大小：1007 K

文摘

•: Cue reactivity incubates during forced abstinence from cocaine- or sucrose-taking.
•: Incubation aligns with lower potency of 5-HT_2CR agonist to suppress cocaine cue reactivity.
•: Incubation of cocaine cue reactivity associates with lower 5-HT_2CR expression in mPFC.
•: Membrane to cytoplasmic 5-HT_2CR ratio inversely correlates with cocaine cue reactivity.

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