Characterization of neuropathology in the HIV-1 transgenic rat at different ages

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Characterization of neuropathology in the HIV-1 transgenic rat at different ages

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作者：William C. Reid^a ; ¹ ; Wael G. Ibrahim^a ; ¹ ; Saejeong J. Kim^b ; Frank Denaro^c ; Rafael Casas^a ; Dianne E. Lee^a ; Dragan Maric^d ; Dima A. Hammoud^a ; ^{hammoudd@cc.nih.gov" class="auth_mail" title="E-mail the corresponding author}
关键词：ART ; antiretroviral therapy ; CC ; corpus callosum ; CSF ; cerebrospinal fluid ; CX ; cortex ; HAART ; highly active antiretroviral therapy ; HAD ; HIV associated dementia ; HAND ; HIV-1 associated neurocognitive disorders ; HC ; hippocampus ; IACUC ; Institutional Animal Care and Use Committee ; PCNA ; proliferating cell nuclear antigen ; PET ; positron emission tomography ; ST ; striatum ; SVZ ; subventricular zone ; Tg ; HIV-1 transgenic ; TH ; tyrosine hydroxylase ; WT ; wild type
刊名：Journal of Neuroimmunology
出版年：2016
出版时间：15 March 2016
年：2016
卷：292
期：Complete
页码：116-125
全文大小：1893 K

文摘

•: Astrocytic damage dominates the neuropathology in HIV-1 Tg rats.
•: No neurogenesis abnormalities in the Tg rat suggesting neurodegenerative process
•: CSF gp120 levels higher than serum in some Tg rats suggesting local production

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