ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

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ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

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作者：Mark D. Borromeo¹ ; ⁸ ; Trisha K. Savage¹ ; ⁸ ; Rahul K. Kollipara² ; ⁸ ; Min He³ ; Alexander Augustyn⁴ ; Jihan K. Osborne³ ; Luc Girard³ ; ⁴ ; ⁵ ; John D. Minna³ ; ⁴ ; ⁵ ; ⁶ ; Adi F. Gazdar⁴ ; ⁵ ; ⁷ ; Melanie H. Cobb³ ; ⁵ ; Jane E. Johnson¹ ; ³ ; ⁵ ; ^{jane.johnson@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：2 August 2016
年：2016
卷：16
期：5
页码：1259-1272
全文大小：5682 K

文摘

•: Heterogeneity in neuroendocrine lung cancer (SCLC) is revealed by ASCL1 and NEUROD1
•: In vivo requirement for ASCL1 exists in SCLC tumor formation
•: ASCL1 directly regulates known oncogenes in SCLC
•: Current SCLC mouse models reflect a ASCL1^High; NEUROD1^Low subtype

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