Regional specific modulation of neuronal activation associated with nitric oxide synthase inhibitors in an animal model of antidepressant activity

详细信息查看全文

作者：Eoin Sherwin^a ; ^c ; Valentina Gigliucci^b ; ^c ; Andrew Harkin^b ; ^c ; ^{aharkin@tcd.ie" class="auth_mail" title="E-mail the corresponding author}
关键词：Stress ; Forced swimming test ; 5-HT ; nNOS ; c-FOS ; ΔFosB
刊名：Behavioural Brain Research
出版年：2017
出版时间：1 January 2017
年：2017
卷：316
期：Complete
页码：18-28
全文大小：2986 K

文摘

•: NOS inhibitors reduce immobility time and increase FST-induced c-FOS immunoreactivity in the lateral septum.
•: NOS inhibitors reduce FST-induced c-FOS immunoreactivity in the dorsal dentate gyrus, ventral CA1 and dorsal raphe nucleus.
•: Treatment with pCPA and restraint stress provokes a reduction in delta FosB in the lateral septum.
•: pCPA and restraint stress provoke an increase in delta FosB in the infra-limbic cortex and nucleus accumbens.
•: Regional changes in the expression of delta FosB relate to increased immobility in the FST.