Niclosamide induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes
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文摘
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Niclosamide showed pro-apoptosis effect on RA FLS but not affected normal FLS.

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Niclosamide-induced apoptosis in RA FLS was achieved via a mitochondrial-dependent pathway.

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Niclosamide regulated the expressions of Bax and Bcl-2 and release of cytochrome C.

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AKT was also required for Niclosamide-induced apoptosis in RA FLS.

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