The Tumor Suppressor LKB1 Emerges as a Critical Factor in Hematopoietic Stem Cell Biology

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• 作者：Bryan Krock¹ ; Nicolas Skuli¹ ; ² ; M. Celeste Simon¹ ; ² ; ³ ; ^{celeste2@mail.med.upenn.edu}
• 刊名：Cell Metabolism
• 出版年：2011
• 出版时间：5 January 2011
• 年：2011
• 卷：13
• 期：1
• 页码：8-10
• 全文大小：189 K

文摘

How cellular metabolism regulates stem cell function is poorly understood but is an emerging field of study. In a recent issue of Nature, three independent groups demonstrate that LKB1 promotes hematopoietic stem cell (HSC) quiescence and metabolic homeostasis. Surprisingly, these effects on HSCs occur independently of AMPK/mTOR and FoxO signaling.