Early use of posaconazole in the successful treatment of rhino-orbital mucormycosis caused by Rhizopus oryzae

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• 作者：Jen Kok ; Nicole Gilroy ; Catriona Halliday ; Ok Cha Lee ; Daniel Novakovic ; Patrick Kevin ; Sharon Chen
• 关键词：Rhino-cerebral mucormycosis ; Rhizopus oryzae ; Posaconazole
• 刊名：Journal of Infection
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：55
• 期：3
• 页码：e33-e36
• 全文大小：214 K

文摘

Mucormycosis is a potentially fatal, rapidly destructive, opportunistic infection often seen in immunocompromsied individuals and patients with diabetes mellitus. We describe two patients with rhino-orbital mucormycosis caused by Rhizopus oryzae who received posaconazole within 7 days of diagnosis and in whom cure was achieved in conjunction with extensive surgical resection of diseased tissue. Posaconazole was well-tolerated. Our experience indicates that this new extended-spectrum azole antifungal agent can be used early in the course of zygomycete infection with good results.