Oxaliplatin doublets in non-small cell lung cancer: A literature review

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• 作者：Diego Cortinovis ; Paolo Bidoli ; Nicoletta Zilembo ; Alberto Fusi ; Emilio Bajetta
• 关键词：Oxaliplatin ; Chemotherapy ; Non-small cell lung cancer ; Review ; Doublet chemotherapy regimens ; Platinum analogue
• 刊名：Lung Cancer
• 出版年：2008
• 出版时间：June 2008
• 年：2008
• 卷：60
• 期：3
• 页码：325-331
• 全文大小：150 K

文摘

Nowadays cisplatin doublets are considered the gold-standard treatment in advanced non-small cell lung cancer (NSCLC) patients, but are often associated to poor toxicity profile. In the last years different schedules have been developed in order to improve the tolerability of these regimens. Carboplatin is gradually replacing cisplatin in clinical practice as well as in clinical trials even if it is still unclear whether it has an equivalent efficacy compared to cisplatin. Oxaliplatin, the trans-l oxalato platinum compound, showed encouraging antineoplastic activity and favourable toxicity profile in NSCLC, but confirmatory randomized phase III trials are warranted. We performed a literature search in order to better understand the possible role of oxaliplatin-based combinations in advanced NSCLC treatment strategies.