A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats

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A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats

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作者：Julijana Stanimirovic^a ; ^{julijana1008@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Milan Obradovic^a ; ^{obradovicmilan@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Aleksandra Jovanovic^a ; ^{jovsale@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Emina Sudar-Milovanovic^a ; ^{emma_crash@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Sonja Zafirovic^a ; ^{sonjazafirovic@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Samantha J. Pitt^b ; ^{sjp24@st-andrews.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Alan J. Stewart^b ; ^{ajs21@st-andrews.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Esma R. Isenovic^a ; ^{isenovic@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
关键词：High fat diet ; Sex differences ; Insulin resistance ; Liver metabolism ; Nitrite/nitrate
刊名：Nitric Oxide
出版年：2016
出版时间：1 April 2016
年：2016
卷：54
期：Complete
页码：51-59
全文大小：1075 K

文摘

•: Men and women differ substantially in regard to the severity of IR.
•: HF diet differently modifies nitrite/nitrate production between the sexes.
•: Changes in nitrite/nitrate level are related to changes of Akt, mTOR, PDK-1 activation.
•: This work provides a mechanistic explanation why females are more protected from IR than males.

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