Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients

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Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients

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作者：Galimudi Rajesh Kumar^a ; Kondapalli Mrudula Spurthi^a ; Gundapaneni Kishore Kumar^a ; Tupurani Mohini Aiyengar^a ; Padala Chiranjeevi^a ; Shyamala Nivas^a ; Cingeetham Anuradha^a ; Banapuram Swathi^a ; Sanjib Kumar Sahu^b ; Altaf Ali^a ; Hanumanth Surekha Rani^a ; ^{surekharanih@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Coronary heart disease (CHD) ; Endothelial nitric oxide synthase (eNOS) ; First degree relatives (FDRS) ; Haplotypes ; Linkage disequilibrium (LD) ; RNA-Secondary structures ; Three-dimensional modelling
刊名：Nitric Oxide
出版年：2016
出版时间：30 November 2016
年：2016
卷：60
期：Complete
页码：40-49
全文大小：2260 K

文摘

•: Having an FDR with premature CHD is a significant risk factor for development of CHD.
•: To study the role eNOS polymorphism (eNOS -786T/C, Intron 4b/4a and 894 G/T) in CHD patients and FDRS.
•: eNOS -786 TC, intron 4b/4a, and 894 GT haplotypes (G-C-B and T-C-B) are significantly associated with the development of CHD.
•: It is the first kind of study to investigate eNOS -786 TC, Intron 4b/4a, and 894 GT polymorphisms in FDRS.
•: Higher nitrite/nitrate levels among GCB, TCB haplotypes carriers in FDRS and CHD patients.