Involvement of nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of tropisetron and ondansetron in mice forced swimming test and tail suspension test

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

Involvement of nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of tropisetron and ondansetron in mice forced swimming test and tail suspension test

详细信息查看全文

作者：Arya Haj-Mirzaian^a ; ^b ; ¹ ; Nastaran Kordjazy^a ; ^b ; ¹ ; Shayan Amiri^a ; ^b ; Arvin Haj-Mirzaian^a ; ^b ; Hossien Amini-khoei^a ; ^b ; Sattar Ostadhadi^a ; ^b ; ^c ; AhmadReza Dehpour^a ; ^b ; ^{dehpoura@sina.tums.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; ^{dehpour@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
关键词：5-HT ; 5-hydroxytryptamine ; NO ; nitric oxide ; NOS ; nitric oxide synthase ; iNOS ; inducible nitric oxide synthase ; nNOS ; neuronal nitric oxide synthase ; cGMP ; cyclic guanosine monophosphate ; FST ; forced swimming test ; TST ; tail suspension test ; OFT ; open-field test ; i.p. ; intraperitoneal ; NIH ; National Institutes of Health ; l-NAME ; NG-l-arginine methyl ester ; 7-NI ; 7-nitroindazole ; l-arg ; l-arginine ; PDE ; phosphodiesterase ; ANOVA ; analysis of variance ; PFC ; prefrontal cortex
刊名：European Journal of Pharmacology
出版年：2016
出版时间：5 June 2016
年：2016
卷：780
期：Complete
页码：71-81
全文大小：1874 K

文摘

•: 5-HT₃ antagonists showed an antidepressant effect in the mouse FST and TST.
•: nNOS inhibitor enhanced the effect of 5-HT₃ antagonists in behavioral tests.
•: NO precursor and 5-PDE inhibitor attenuated the effect of 5-HT3 antagonists.
•: 5-HT₃ antagonists and nNOS inhibitor decreased the hippocampal nitrite levels.
•: Antidepressant effect of 5-HT₃ antagonists is partly mediated via NO-cGMP pathway.