Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes

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• 作者：Xiao Man Wu^a ; ^b ; Yi Wei Hu^a ; ^b ; Na Na Xue^a ; ^b ; Shi Si Ren^a ; ^b ; Shan Nan Chen^a ; Pin Nie^a ; Ming Xian Chang^a ; ^{mingxianchang@ihb.ac.cn}
• 关键词：Zebrafish ; NLRC5 ; SVCV infection ; Antiviral activity ; MHC class II transactivator
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：68
• 期：Complete
• 页码：58-68
• 全文大小：2354 K
• 卷排序：68

文摘

Zebrafish NLRC5 has a monopartite NLS, and localizes in the entire cell including the nucleus. Zebrafish NLRC5 was detected at the early stages of development with higher expression in embryo than in larvae. Zebrafish NLRC5 was induced by both bacterial and viral infection. Zebrafish NLRC5 is involved in IFN-independent antiviral response. Zebrafish NLRC5 functions as a transcriptional regulator of MHC class II genes.