NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide

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• 作者：Wei Zhu^a ; ^b ; Feng-Sheng Cao^c ; Jun Feng^a ; Hua-Weng Chen^a ; Jie-Ru Wan^b ; Qing Lu^d ; ^{qinglu@mail.hust.edu.cn} ; Jian Wang^b ; ^{jwang79@jhmi.edu}
• 关键词：ASC ; apoptosis-associated speck-like protein ; ELISA ; enzyme-linked immunosorbent assay ; IL ; interleukin ; LPS ; lipopolysaccharide ; NLRP3 ; nod-like receptor pyrin domain-containing protein 3 ; TNFα ; tumor necrosis factor α
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：343
• 期：Complete
• 页码：77-84
• 全文大小：817 K
• 卷排序：343

文摘

Depression-like behaviors and memory deficit appear in the late stage of mice injected with LPS. NLRP3 inflammasome activates microglia and increases inflammatory response. NLRP3 inflammasome inhibition reverses these effects.