NLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model

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• 作者：Wen-Jun Su^a ; ¹ ; Yi Zhang^a ; ^b ; ¹ ; Ying Chen^c ; Hong Gong^a ; Yong-Jie Lian^a ; Wei Peng^a ; Yun-Zi Liu^a ; Yun-Xia Wang^a ; Zi-Li You^d ; Shi-Jie Feng^e ; Ying Zong^e ; Guo-Cai Lu^e ; ^{newdrug@smmu.edu.cn} ; Chun-Lei Jiang^a ; ^{cljiang@vip.163.com}
• 关键词：NLRP3 inflammasome ; Knockout ; Interleukin-1β ; Depression ; Stress ; Inflammation
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：30 March 2017
• 年：2017
• 卷：322
• 期：part_PA
• 页码：1-8
• 全文大小：1344 K
• 卷排序：322

文摘

CUMS-induced depression-like behavior needs participation of NLRP3 inflammasome. NLRP3 gene knockout blocks activation of NF-κB protein complex in CUMS-induced depression mouse model. The NLRP3 inflammasome regulates CUMS-induced MAPK pathway activation.