The Bacterial T6SS Effector EvpP Prevents NLRP3 Inflammasome Activation by Inhibiting the Ca²⁺-Dependent MAPK-Jnk Pathway

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• 作者：Hao Chen¹ ; Dahai Yang¹ ; Fajun Han¹ ; Jinchao Tan¹ ; Lingzhi Zhang¹ ; Jingfan Xiao¹ ; ² ; Yuanxing Zhang¹ ; ² ; ³ ; Qin Liu¹ ; ² ; ³ ; ⁴ ; ^{qinliu@ecust.edu.cn}
• 关键词：T6SS effector ; NLRP3 inflammasome ; ASC oligomerization ; Jnk ; calcium
• 刊名：Cell Host & Microbe
• 出版年：2017
• 出版时间：11 January 2017
• 年：2017
• 卷：21
• 期：1
• 页码：47-58
• 全文大小：3597 K
• 卷排序：21

文摘

E. tarda utilizes a T6SS to negatively regulate NLRP3 inflammasome activation The T6SS effector EvpP is identified and shown to inhibit NLRP3 inflammasome EvpP suppresses ASC oligomerization by regulating a Ca2+-dependent Jnk pathway EvpP-mediated inflammasome inhibition promotes E. tarda colonization in mice