Membrane binding, endocytic trafficking and intracellular fate of high-affinity antibodies to gangliosides GD1a and GM1

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• 作者：Fernando M. Ruggiero^a ; Aldo A. Vilcaes^a ; Nobuhiro Yuki^b ; José ; L. Daniotti^a ; ^{daniotti@dqb.fcq.unc.edu.ar}
• 关键词：Anti-ganglioside antibody ; Endocytosis ; Ganglioside ; Intracellular trafficking ; Autoimmune neuropathy
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1859
• 期：1
• 页码：80-93
• 全文大小：2229 K
• 卷排序：1859

文摘

Binding, endocytic trafficking and fate of antibodies to gangliosides GD1a and GM1 Cell internalization of antibody to GD1a is regulated by ADP-ribosylation factor 6. Antibodies to gangliosides behave in an epitope- and cell type-dependent manner.