In vitro effect of 4-nonylphenol on human chorionic gonadotropin (hCG) stimulated hormone secretion, cell viability and reactive oxygen species generation in mice Leydig cells

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• 作者：Tomá ; &scaron ; Jambor^a ; ^{tomasjambor1@gmail.com} ; Eva Tvrdá ; ^a ; ^{evina.tvrda@gmail.com} ; Eva Tu&scaron ; imová ; ^a ; ^{tusimova.eva@gmail.com} ; Anton Ková ; čik^a ; ^{anton.kovacik@yahoo.com} ; Jana Bistá ; ková ; ^a ; ^{jana312@gmail.com} ; Zsolt Forgá ; cs^b ; ^{zforgacs@gmail.com} ; Norbert Luká ; č^a ; ^{norbert.lukac@uniag.sk}
• 关键词：4-nonylphenol ; Human chorionic gonadotropin ; Hormones ; Viability ; Reactive oxygen species
• 刊名：Environmental Pollution
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：222
• 期：Complete
• 页码：219-225
• 全文大小：1027 K
• 卷排序：222

文摘

4-nonylphenol decrease production of dehydropiandrosterone after 44 h of cultivation. 4-nonylphenol significantly inhibited androstenedione formation after 44 h. 4-nonylphenol decrease testosterone secretion, but not significantly after 44 h Leydig cells viability was significantly increased after 44 h treatment. 44 h treatment of 4-nonylphenol caused significant intracellular accumulation of ROS.