Embryonic cerebellar granule cells are resistant to necrosis induced by homocysteine

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• 作者：Nicola S.L. Foister ; Ceri E. Oldreive ; John B. Mackie and Gayle H. Doherty
• 关键词：Caspase ; Cerebellum ; Development ; Homocysteine ; Mouse ; Neurodegeneration
• 刊名：Developmental Brain Research
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：160
• 期：1
• 页码：85-89
• 全文大小：298 K

文摘

Hyperhomocysteinemia is a risk factor for a range of neurodegenerative conditions, yet its effects in the developing nervous system have been poorly elucidated. We studied the in vitro response of cerebellar granule neurons (CGCs) to homocysteine. We have shown that embryonic CGCs are resistant to homocysteine-induced neurotoxicity, whilst postnatal CGCs are not. This is the first demonstration of a neuronal population undergoing a developmental switch in their response to homocysteine. Greater understanding of this change may have important implications for both neurodegenerative conditions and neurodevelopmental disorders.