Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro

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• 作者：Ceri E. Oldreive ; Jenni Harvey ; Gayle H. Doherty
• 关键词：Cell death ; Cerebellum ; Leptin ; Granule ; Neurite ; Purkinje
• 刊名：Neuroscience Letters
• 出版年：2008
• 出版时间：13 June 2008
• 年：2008
• 卷：438
• 期：1
• 页码：17-21
• 全文大小：494 K

文摘

As recent evidence has revealed a pro-survival role for the anti-obesity hormone leptin in the nervous system, we investigated the generality of this finding on cerebellar Purkinje and granule neurons in vitro. We found that whilst leptin promoted cerebellar Purkinje neuron survival, it had no affect on cerebellar granule cells. In addition, we discovered that leptin promoted both the outgrowth of neurites from cerebellar Purkinje neurons and increased the complexity of the neurite arbor. Thus, leptin has different effects on two neighbouring populations of neurons within the cerebellum implying specificity of its actions in the central nervous system.