Tick-borne encephalitis: Pathogenesis and clinical implications

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• 作者：Daniel Rů ; ž ; ek ; Gerhard Dobler ; Oliver Donoso Mantke
• 关键词：Tick-borne encephalitis ; Tick-borne encephalitis virus ; Pathogenesis ; Clinical data
• 刊名：Travel Medicine and Infectious Disease
• 出版年：2010
• 出版时间：July 2010
• 年：2010
• 卷：8
• 期：4
• 页码：223-232
• 全文大小：861 K

文摘

Summary

Tick-borne encephalitis (TBE) is an important and severe neurological illness occurring in large areas of Europe and northern Asia. Only a small proportion of those infected develop clinical symptoms. The symptomatic cases are, however, characterized with fevers and debilitating encephalitis that might progress into chronic disease or fatal infections. This review summarizes data on clinical presentation, pathogenesis and pathology of TBE in humans, and of experimental TBE in animal models with the purpose to explain why is TBE such a severe disease clinically.